Twenty-one hours was not enough to end 47 years of hostility between Iran and the US.


The historic high-level talks in Islamabad, during a pause in weeks of grievous war, were always unlikely to end any other way.


Calling this marathon negotiating session a failure belies the scale of the challenge in narrowing wide gaps on complex issues ranging from age-old suspicion about Iran's nuclear programme to new challenges this war has thrown up - most of all Iran's control of the strategic Strait of Hormuz, whose closure is causing economic shocks worldwide.


To do a deal, they also needed to overcome a deep chasm of distrust.


A day ago, it wasn't even certain the two sides would meet, and even more, sit down in the same room.


A longstanding political taboo was broken.


The urgent question now is: what happens next?


What happens to the contested two-week ceasefire which pulled the world back from US President Donald Trump's alarming threat to destroy a whole civilisation in Iran?


Would the US president be ready to send his negotiators back to the bargaining table?


We're hearing reports from sources here in Islamabad that some conversations have continued after US Vice-President JD Vance boarded his plane at sunrise, declaring the US delegation had made their final and best offer.


Will the US now escalate or negotiate?


Both the US and the Iranian delegations came to Islamabad emboldened by their belief that theirs was the winning side in this war.


And they engaged knowing that, if they failed, there was the option to keep fighting – whatever the spiralling pain for their own people and a world reeling from the cost of this conflagration.


The vice-president spoke of the core goal of the US during his brief dawn news conference, detailing expectations for Iran to commit to not pursuing nuclear weapons.


Iran's foreign ministry spokesman criticized the US's excessive demands and unlawful requests in this round of talks, indicating readiness to continue dialogue amid fragile ceasefire conditions.


If history provides any lessons, the last significant deal with Iran in 2015 took 18 months to achieve. As both sides reflect on their next steps, the world remains on alert.